
Nortriptyline, a tricyclic antidepressant (TCA), is sometimes used off-label to manage pain associated with Interstitial Cystitis (IC) or Bladder Pain Syndrome (BPS). While studies suggest it can reduce symptoms in some individuals, it’s not a guaranteed cure and may not eliminate all symptoms.
NOTE: I am not a medical professional. The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this web site is for general information purposes only.
Drugs.com reviews indicate a generally positive experience for pain relief, with a rating of 7.3 out of 10 and 69% of reviewers reporting positive experiences.

Nortriptyline is used to treat some types of persistent pain. It is especially good for nerve pain such as burning🔥, shooting or stabbing pain, and for pain that keeps you awake at night. The dose of Nortriptyline needed for pain relief is often lower than that prescribed for depression.
Nortriptyline works by increasing the amount of specific nerve transmitters in the nervous system, reducing pain messages arriving in the brain.
Nortriptyline works by increasing the amount of specific nerve transmitters in the nervous system, reducing pain messages arriving in the brain 🧠.
If you’re taking Nortriptyline for depression, it’s thought to work by increasing a chemical called serotonin in the brain 🧠. This helps to improve your mood.
Is Nortriptyline a muscle relaxer? Yes. Nortriptyline is prescribed to relieve one from pain. As per a study, Nortriptyline can effectively relax the vascular smooth muscles of precontracted arteries due to noradrenaline or KCl.
Read testimonies below regarding using nortriptyline for pain.
Testimonials

Testimony #1
“You name it, I have every back problem known to man. I have been on this medicine for only a month. And I live a pain-free life. I do have hyperactivities, but that’s disappearing. Dry mouth and no appetite, and without eating as much, my blood sugar levels have been wonderful (hypoglycemia). I love the way I feel, I have told many people, this is a miracle.”
Testimony #2
“12 years of severe facial pain and misdiagnosed on numerous occasions with sinus infections. Multiple trips to the dentist, root canals, extractions, teeth fillings removed and replaced with porcelain ones. Septoplasty by ENT specialist. Numerous doses of antibiotics and tramadol for pain. I told all this to a doctor that listened and he turned to me and said ‘You have trigeminal neuralgia’. I was given Gabapentin, which didn’t work. Went back and was put on nortriptyline. After 12 years, I am pain-free.”
Sources

https://www.britishpainsociety.org/static/uploads/resources/files/FPM-Nortriptyline_0.pdf
https://pmc.ncbi.nlm.nih.gov/articles/PMC6485407/
https://www.dgft.nhs.uk/wp-content/uploads/2021/03/Nortriptyline-for-the-treatment-of-pain-V2-1.pdf
https://www.yashodahospitals.com/medicine-faqs/nortriptyline/
https://pmc.ncbi.nlm.nih.gov/articles/PMC7258371/
# Interstitial Cystitis
# Bladder
# Cystite interstitielle
# Vessie
# Cistitis Intersticial
# Vejiga
# 間質性膀胱炎
# Kanshitsuseibōkōen
# अंतराकाशी मूत्राशय शोथ
# moothrasanji
# 간질성 방광염
# ganjilseong bang-gwang-yeom
# ഇന്റർസ്റ്റീഷ്യൽ സിസ്റ്റിറ്റിസ്
# intersticial sistittis
bladder pain syndrome

